Drug addiction is defined as a compulsive pattern of drug-seeking- and taking- behavior, with recurrent episodes of abstinence and relapse, and a loss of control despite negative consequences.Addictive drugs promote reinforcement by increasing dopamine in the mesocorticolimbic system, which alters excitatory glutamate transmission within the reward
Climate change, urbanisation and population growth are creating the necessity in urban systems to integrate the management of water resources which volume been significantly declined.Several cities are already feeling water stress.The solution is to conceptualise Smart Cities that are considering aspects of effective water resources management.Coun
The precise roles that oxidants play in lifespan and aging are still unknown.Here, we report the discovery that chronologically aging yeast cells undergo a sudden redox collapse, which affects over 80% of identified thiol-containing proteins.We present evidence that this redox collapse is not triggered by an increase in endogenous oxidants as would
Acute limb ischemia (ALI) represents one of the most common emergent scenarios encountered by babies a vascular specialist.Despite expedient revascularization, high rates of limb loss are reported along with high mortality rates which are second only to ruptured abdominal aortic aneurysms.Surgical revascularization is standard of care.Endovascular